Biomedical Engineering Reference
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Fig. 3
Illustration of multi-vesicular assemblies produced via a two-stage double emulsion of
poly(AAc-
co
-DSA). The resulting vesicles are equipped with pH-responsive transmembrane
channels. (Reproduced from ref. Chiu et al.
2008
)
130
-
b
-poly(2-diethylaminoethyl methacrylate)
120
(PEO
45
-
b
-PS
130
-
b
-PDEA
120
).
Self-assembly into vesicles was carried out at a pH of ca
.
10.4. The vesicle wall
was shown by cryo-TEM to consist of a sandwich of two external ca
.
4 nm thick
continuous PS layers and one ca
.
17 nm thick PDEA layer in the middle (Fig.
4
).
As the pH decreases, both the vesicle size and the thickness of all three layers
increase. The increase of the thickness of the intermediate PDEA layer arises from
the protonation and hydration, but the swelling is constrained by the PS layers.
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