Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery - Intracellular Delivery: Fundamentals and Applications - page 282

The demanding challenge of the future research in this field is to find the right
carrier architecture and optimum polymer chemistry that can improve the delivery
of sophisticated and complex therapeutic agents (e.g., poorly soluble drugs, pro-
teins and genes) to their cellular and intracellular targets. For a potential clinical
application, barriers like high drug loading, stable drug encapsulation, controlled
drug release, and micelle-cell interaction should be addressed, a large-scale good
manufacturing practice (GMP) production procedure should be developed, and the
safety profile needs to be established.
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