Biomedical Engineering Reference
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Fig. 12
(
a
) Preparation of cRGDfK-PEO-PCL micelles with physically loaded DOX (Reproduced
from Nasongkla et al.
2004
with permission). (
b
) Preparation of RGD-PEO-PCL micelles with
chemically conjugated DOX or physically loaded DOX
after 3 h incubation with mouse melanoma B16-F10 cells was observed for GRGDS
modified micelles compared to unmodified micelles. RGD modified micelles bearing
conjugated DOX demonstrated higher cytotoxicity on B16-F10 cells than the control
conjugate without the RGD modification (Xiong et al.
2007b, 2008a
).
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