Biomedical Engineering Reference
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O
O
PEO
-b
-P(
L
-Asp)-DOX
CH
3
O
CH
2
CH
2
NH
C CH
NH
C
H
CH
2
CH
NH
n
y
x
CH
2
C
C
O
R
O
R
R = OH or
DOX
O
H
3
C O CH
2
CH
2
NH C CH
NH
H
PEO-
b
-P(
L
-
Asp--Hyd-DOX)
n
m
CH
2
C
O
NH
N
O
OH
OH
OH
OH
O
OH
O
O
CH
3
OH
NH
2
Fig. 7
Example structures of PEO-PLAA-anticancer drug conjugates
O
O
PEO
-b
-P(
L
-Asp)-CDDP
CH
3
O CH
2
CH
2
NH C CH NH
C
CH
2
CH NH
H
n
y
x
CH
2
C
C
O
Na
O
Na
O
O
PLAA
O
PEO
-b
-P(
L
-Glu)-CDDP
NH
C
CH
NH
H
CH
3
O CH
2
CH
2
COO
OOC
NH
3
n
NH
3
x
Pt
CH
2
CH
2
C
O
O
Pt
NH
3
NH
3
COO
OOC
Na
Cl
PLAA
NH
3
Pt
Self-assembly
NH
3
Cl
CDDP: Cisplatin
Fig. 8
Formation of complex between PEO-PLAA with CDDP and their self assembly
component of the block copolymers at acidic pHs (e.g., for intratumoral drug
delivery), or deprotonation of base sensitive groups at basic pHs (e.g., for intestinal
drug delivery). In this category, the polymers mostly bear ionizable groups of
a weak acid (carboxylic acid) or weak base (amino group) (Benns et al.
2000
;
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