Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery - Intracellular Delivery: Fundamentals and Applications - page 262

Fig. 5 Schematic model and chemical structure of NK105 (Reproduced from Hamaguchi et al.
2005a with permission)
rate from the micellar core, ultrasound-induced rapid micellar dissociation and
re-association, or ultrasound-induced formation of transient collapsed cavitation
(Fig. 9 ) (Pitt et al. 2004 ; Husseini et al. 2002 ; Munshi et al. 1997 ). Application of
ultrasound was shown to increase the cellular internalization and cytotoxicity of
both free and Pluronic ® P105 micellar formulation of DOX against Human
Leukemia HL-60 cells (Husseini et al. 2000 ; Rapoport et al. 2002 ). Rapoport et al.
demonstrated that the cellular uptake and nuclear association of encapsulated DOX
to be substantially enhanced after exposure to ultrasound leading to an increased
cytotoxicity of DOX loaded Pluronic ® micelles in resistant A2780/ADR cells
(Marin et al. 2001 ; Rapoport 2004 ; Rapoport et al. 2004 ; Nelson et al. 2002 ). Pitt
et al. reported on the in vivo antitumor efficacy of Plurogel formulations of DOX