Amphiphilic Block Copolymer Based Nanocarriers for Drug and Gene Delivery - Intracellular Delivery: Fundamentals and Applications - page 259

Fig. 3 General scheme for the release of incorporated molecule from polymeric micellar drug
conjugates; micellar nano-containers and polyion complex (PIC) micelles (Adopted from Aliabadi
and Lavasanifar 2006 with permission)
the -COOH side groups in PEO-poly(a-carboxyl-e-caprolactone) (PEO-PCCL)
and amine group of DOX. At early studies the degree of DOX conjugation
reached 20% (molar ratios).
PEO-PLAA block copolymers have also been extensively used for chemical con-
jugation of drugs to the core-forming block via ester, amide, hydrazone, or disulfide