Biomedical Engineering Reference
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Poly(Alkyl Cyanoacrylate) Nanosystems
Julien Nicolas and Christine Vauthier
Abstract
Poly(alkyl cyanoacrylate) nanosystems include various types of
nanoparticles suitable to achieve in vivo drug delivery in a well controlled
manner. Starting from general features on the synthesis of alkyl cyanoacrylate
monomers and of their polymerization, this chapter aims to discuss how these
monomers and corresponding polymers can be used to design drug delivery
nanosystems with different properties.
Keywords
Alkyl cyanoacrylate
•
Anionic polymerization
•
Copolymers
•
Free radical
polymerization
•
Nanocapsules
•
Nanospheres
•
Zwitterionic polymerization
Abbreviations
(PIB-CA)
3
three-arm star cyanoacrylate-telechelic polyisobutylene
ACA
alkyl cyanoacrylate
AIBN
azobisisobutyronitrile
Apo B-100
apolipoprotein B-100
Apo E
apolipoprotein E
Apo E3
apolipoptotein E3
BBB
blood-brain barrier
BFs
breath figures method
DCC
N
,
N
'-dicyclohexylcarbodiimide
ddI
didanosine
DXM
dexamethasone
ECA
ethyl cyanoacrylate
J. Nicolas and C. Vauthier (
*
)
Physico-chimie, Pharmacotechnie, Biopharmacie, Univ Paris-Sud,
UMR 8612, Chatenay-Malabry F-92296, France
and
CNRS, Chatenay-Malabry F-92296, France
e-mail: christine.vauthier@u-psud.fr
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