Biomedical Engineering Reference
In-Depth Information
Mass Transport via Cellular Barriers
and Endocytosis
Silvia Ferrati, Agathe K. Streiff, Srimeenakshi Srinivasan,
Jenolyn F. Alexander, Nikhil Bhargava, Andrew M. Peters, Nelly E. Song,
Ennio Tasciotti, Biana Godin, Mauro Ferrari, and Rita E. Serda
Abstract
Mass transport within body compartments and across biological barriers
negatively impacts drug delivery but also presents opportunities to optimally design
drug carriers that benefit from novel differentials presented in pathological tissue.
As an example, cancer presents unique alterations in vascular permeability, osmotic
pressure, cellular zip-codes, and numerous other physical parameters that can be
used to achieve preferential accumulation of imaging and therapeutic agents at the
cancer lesion. This chapter describes the journey of drug delivery from the site of
administration to the appropriate subcellular compartment within the target cell.
Design parameters for optimal fabrication of nanoparticle-based carriers, including
size, shape, elemental composition, surface staging, and hierarchical ordering of
multi-particle complexes are presented. The overall objective of this chapter is to
enhance our understanding of mass transport in order to facilitate the development
of carriers for therapy and diagnostics of various pathological conditions.
Keywords
Mass transport
•
Cellular targeting
•
Drug delivery
•
Endocytosis
•
Nanoparticle
•
Cellular zip codes
•
Nanoparticle carriers
•
Multi-particle complexes
•
Nanoparticle parameter tuning
•
Particle delivery
•
Intracellular transportation
•
Intracellular delivery
•
Paracellular transport
S. Ferrati, A.K. Streiff, S. Srinivasan, N. Bhargava, A.M. Peters, and N.E. Song
Department of Nanomedicine and Biomedical Engineering, University of Texas Graduate
School of Biomedical Sciences at Houston, Houston, TX 77030, USA
S. Ferrati, S. Srinivasan, J.F. Alexander, E. Tasciotti, B. Godin, and M. Ferrari
Department of Nanomedicine, The Methodist Hospital Research Institute,
6670 Bertner Ave, MS R7-414, Houston, TX 77030, USA
M. Ferrari
Department of Bioengineering, Rice University, Houston, TX 77005, USA
R.E. Serda (
*
)
Department of Nanomedicine, The Methodist Hospital Research Institute,
6670 Bertner Ave, MS R7-414, Houston, TX 77030, USA
e-mail: reserda@tmhs.org
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