Biomedical Engineering Reference
In-Depth Information
Intracellular Delivery: A Multifunctional
and Modular Approach
Rupa R. Sawant and Vladimir P. Torchilin
Abstract
Intracellular delivery of drugs and nucleic acids has become one of the
most widely explored areas of research. However, it has become increasingly
evident that it is also necessary to control the nanocarrier's disposition within a cell.
Much attention has been paid nowadays to control the distribution of the nanocar-
rier within the cell by using organelle targeted nanocarriers. In this review we have
described various approaches developed in our laboratory for intracellular delivery
of drugs and nucleic acids with lipid-based nanocarriers.
Keywords
Cell penetrating peptides
•
Nanocarrier
•
Intracellular delivery
•
pH-sensitive
•
Organelle targeting
Abbreviations
EPR
enhanced permeability and retention
PEG
polyethylene glycol
PEG-PE
polyethylene glycol-phosphatidyl ethanolamine
CPPs
cell penetrating peptides
LL
Lipofectin
®
lipids
PTDs
protein Transduction Domains
HIV-1
human immunodeficiency virus type 1
pNP-PEG-PE
(
p
-nitrophenyl) carbonyl-PEG-PE
QDs
quantum dots
APC
antigen presenting cells
PC
egg phosphatidylcholine
Chol
cholesterol
R.R. Sawant and V.P. Torchilin (
*
)
Department of Pharmaceutical Sciences and Center for Pharmaceutical
Biotechnology and Nanomedicine, Northeastern University, Mugar Building,
Room 312, 360 Huntington Avenue, Boston, MA 02115, USA
e-mail: v.torchilin@neu.edu
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