Biomedical Engineering Reference
In-Depth Information
Fig. 8
Whole body 3D-micro MR imaging of mice injected with 0.033 mmol Gd/kg of generation
4 polypropyleneimine diaminobutane dendrimer conjugated with 64 IB4M-Gd (panel
a
and
b
) or
generation 4 polyamidoamine dendrimer conjugated with 64 IB4M-Gd (panel
c
and
d
). Panels
(
a
) and (
c
) represent imaged taken within 2 min of IV dosing of dendrimer and panels (
b
) and
(
d
) represent images taken 10 min after IV injection (Reproduced from Kobayashi et al. (
2001b
).
With permission)
or improved drug delivery to lymph nodes, specific delivery of toxic agents to
prevent macrophage activity and delivery of antigens to promote immunization. For
instance, Amphotericin B liposomes are used to target macrophage resident fungal
infections. Each of these goals requires specific internalization within target
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