Biomedical Engineering Reference
In-Depth Information
Nanosized Drug Delivery Vectors
and the Reticuloendothelial System
Lisa M. Kaminskas and Ben J. Boyd
Abstract
Nanomaterials have potential as drug delivery vectors that can improve
the chemical stability and pharmacokinetic profile of small molecule drugs or
improve drug uptake into solid tumours. However, one consequence of the use of
nanosized drug delivery vectors is their potential recognition by tissue macrophages
and accumulation in organs of the reticuloendothelial system (RES). While in some
instances the uptake of drug loaded nanomaterials or 'nanomedicines' into organs
of the RES is favoured, in most instances uptake into the RES can limit systemic
exposure of the nanomedicine and limit therapeutic utility. Hence, this section dis-
cusses ways in which the RES uptake of nanomedicines can either be promoted or
inhibited. Specifically, the effect of various physicochemical properties and pres-
ence or absence of key RES 'recognition ligands' on RES uptake are examined.
Keywords
Drug delivery
•
Macrophage
•
Nanomedicine
•
Opsonisation
•
Reticuloendothelial
Abbreviations
RES
Reticuloendothelial system
PAMAM
Polyamidoamine
PEG
Polyethylene glycol
DPPC
Dipalmitoyl phosphatidylglycerol
Succinate
Succinic acid
Ph-sulphonate
Benzene sulphonate
Ph-disulphonate
Benzene disulphonate
TIM
T cell Ig domain and mucin domain
L.M. Kaminskas and B.J. Boyd (
*
)
Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia
e-mail: ben.boyd@monash.edu
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