Biomedical Engineering Reference
In-Depth Information
4.3
Role of Exocytosis Based Recycling in the Drug Delivery
With the knowledge of the previous results we can conclude that amount of delivered
drug is affected also by the exocytosis.
The useful exocytic processes transport drug containing NV_D vehicle through
the plasma membrane back to the external phase. Accordingly, this recycling helps
to deliver more drug. The useless exocytosis transports a given part of the released
NV and NV_L complex through the plasma membrane back to the external phase.
This causes a delayed degradation only.
In computational analysis, we can derive hypothetical studies that cannot be
realized experimentally. In the following model, we switched off the exocytosis,
fully (note that various inhibitors can only do this partially). The results, illustrated
in Figs.
12
and
13
are compared with same diagrams obtained with switched on
exocytosis (in Figs.
6
and
7
), with same time scale.
Figure
12
illustrates the amount of the initial, external and terminal components.
Having reached the limit values only the degradation follows slowly.
Fig. 12
External, initial and terminal components without exocytosis
Fig. 13
Transient components without exocytosis
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