Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool - Intracellular Delivery: Fundamentals and Applications - page 146

Fig. 7 Transient components

period the motor proteins will bind various complexes, but later on all of them are
either delivered, or degraded, and finally the motor proteins will be free again. The
receptor containing components converge to zero. The external concentration of
NV and NV_L is greater than the same for NV_D, because it can deliver D after
recycling.

4 Analysis of Hypothetical Case Studies

4.1 Comparison of the Individual Mechanisms

It is an interesting question how the three mechanisms (FPM/NAE, RME and
LRME) collectively contribute to drug delivery. It provides the investigator a
chance to tune the model with the knowledge of the expert's considerations (say,
the percentage of receptor mediated endocytosis is estimated to be 70%, etc.).
DCM fully supports the discrete, structural changes, directly. Accordingly, we
can switch off two mechanisms, only by changing the status flag of two elementary
processes from 'y' to 'n'.
In the following two series of Figures we compare the dynamically interesting
periods of four models, as follows:

complex model: upper left diagrams,
mechanism RME alone: upper right diagram,