Biomedical Engineering Reference
In-Depth Information
the hypothetical simulations can also help to find the most effective possible measure-
ments from the identification point of views.
The simulated results can be seen in Figs.
6
and
7
. Because of the different
volume of the various compartments, we show the calculated extensive amounts
instead of concentrations, for the easier comparison. In the following Figures you
will see the changes in the concentration of the various components, calculated
by the hypothetical, simplified model, with the roughly estimated parameters,
summarized in Tables
2
and
3
. The results come from the automatic solution of
the automatically generated model, prepared from the appropriate description
language.
Figure
6
gives an overview of initial, external and terminal components. The
Figure shows an explicit picture, outlining the utilization of the drug. The external
drug level continuously decreases, and it is consumed within 10 min. Afterwards,
the cell utilizes (or decomposes) the drug molecules, present in the various com-
plexes. It is to be noted that we illustrated all of the targets. However, in real cases
it might be very rare. Usually drugs travel to the cytosol or to mitochondria, while
genes enter the nucleus. In our hypothetical example, the mitochondria target is
preferred, followed by the nucleus target. Actually, there is a considerable overall
degradation rate. Please pay attention to the fact that everything is controlled by the
fictitious, hypothetical parameters, tuned according to some qualitative statements
of the field expert.
Figure
7
illustrates the changing amount of transient components. The Figure
depicts the dynamics of the subsequent processes. The injected drug is consumed
within 10 min, and then all of the drug (or gene) containing components converge
to zero. Regarding the exocytosis related components, it is clear that in the first
Fig. 6
Initial, external and terminal components
Search WWH ::
Custom Search