Simulation Based Analysis of Nanocarrier Internalization: Exciting Challenges with a New Computational Tool - Intracellular Delivery: Fundamentals and Applications - page 132

Table 1 (c ontinued)
Process
number Elementary processes Description of the elementary process

R10 le_NV_L_D → cyt_NV_L_D Transport of drug (or gene) containing

NV_L_D complex from the late
endosomes to the cytosol

R11 cyt_NV_L_D → cyt_NV_L + mit_D Transfer of the drug to the mitochondria

R12 cyt_NV_L_D → cyt_NV_L + nuc_D Transfer of the gene (drug) to the nucleus

R13 cyt_NV_L_D + cyt_Targ → cyt_

NV_L + cyt_Targ_D

Delivery of the drug to the target in the
cytosol

R14 cyt_NV_L + cyt_Mot → cyt_Mot_

NV_L

Binding of free nanovehicle NV_L to the
motor protein in the cytosol

R15 cyt_Mot_NV_L → pm_Mot_NV_L Transport of motor protein guided NV_L

complex from the cytosol to the plasma
membrane

R16 pm_Mot_NV_L → pm_NV_L

+ pm_Mot

Decomposition of motor protein guided
NV_L complex in the plasma membrane

R17 pm_Mot → cyt_Mot Transport of motor protein from the plasma

membrane to the cytosol

R18 pm_NV_L → ext_NV_L Exocytosis of nanovehicle complex NV_L

from the plasma membrane to the external
fluid

R19 cyt_NV_D + cyt_Mot → cyt_Mot_

NV_D

Binding of drug (gene) transporting
nanovehicle complex NV_D to the motor
protein in the cytosol

R20 cyt_Mot_NV_D → pm_Mot_NV_D Transport of motor protein guided NV_D

complex from the cytosol to the plasma
membrane

R21 pm_Mot_NV_D → pm_NV_D + pm_

Mot

Decomposition of motor protein guided
NV_D complex in the plasma membrane

R22 pm_NV_D → ext_NV_D Exocytosis of drug (gene) transporting

nanovehicle complex NV_D from the
plasma membrane to the external fluid

R23 cyt_NV_L_D → cyt_Degr Decomposition of drug (or gene) containing

NV_L_D complex in the cytosol

R24 ext_NV_L_D → cyt_NV_L_D Fluid phase macropinocytosis of the complex

NV_L_D from the external phase to the
cytosol

R25 ext_NV_L_D + pm_Lip → pm_Lip_

NV_L_D

Lipid raft mediated endocytosis of drug (or
gene) containing NV_L_D complex to the
plasma membrane

R26 pm_Lip_NV_L_D → cyt_

NV_L_D + pm_Lip

Lipid raft mediated internalization of
NV_L_D complex to the cytosol
with proliferating lipid in the plasma
membrane

R27 cyt_NV_L_D → cyt_NV_D + cyt_

Degr

Degradation of NV_L_D in cytosol

R28 cyt_NV_L → cyt_NV + cyt_Degr Decomposition of NV_L with degradation of

L in cytosol

R29 cyt_NV_L → cyt_Degr Degradation of NV_L in cytosol

(continued)