Biomedical Engineering Reference
In-Depth Information
The primary building elements of the various biological compounds are the
followings: NV: nanovehicle; L: ligand, permitting the association of the drug (D)
with the nanovehicle (NV); D: drug (or gene) to be transported from the external
phase to the prescribed target (to the cytoplasm, to the mitochondria or e.g. in case
of genes to the nucleus); R: receptor, supporting the specific transport through the
plasma membrane; Lip: lipid supporting the specific transport through the lipid
rafts; Targ: target component in the cytoplasm; Degr: fictitious terminating com-
ponent for the degradation of NV, L, R, and D in e.g. ubiquitin containing compo-
nents; Mot: motor proteins, contributing to the exocytosis of nanovehicles and of
the drug.
2.3
Transformations and Transportations
For the better understanding, the “biologically inspired” scheme of our simplified
model is illustrated in Fig. 1 . The Figure shows a cell, surrounded by a plasma mem-
brane in the external phase. The above-mentioned compartments are designated by
colored fields.
Black dots symbolize the various primary components and their derived com-
plex intermediates. There are 34 individual components in the respective phases.
According to the Figure, in the notation
comp_X_Y_…_Z
plasma membrane
external
Mot
R17
cytosol
Mot
mitochondrion
R22
R24
FPM/NAE
D
NV_D
R39
R21
Mot_ NV_D
R11
R20
Targ Targ_D
R
R40
early
late endosome
R13
R19
R38
R10
R1
R7
NV_L_D
NV_L_D
NV_L_D
NV_L_D_R
Mot
R12
R27
NV_D
R14
R4
R2
D
RME
R3
R8
lysosome
R5
R16
R18
R23
R9
Mot_NV_L
nucleus
R15
Mot
Degr
NV_L
R31
Mot_NV
R17
Mot
R6
R32
R33
NV_L
Lip
R30
R28
NV
R29
R34
R26
LRME
R25
R 37
NV
R 36
R 35
FPM/NAE
Fig. 1 Schematic illustration of the investigated model
 
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