Biology Reference
In-Depth Information
Table 4.1
Gene Array Analysis Showing Examples of the Diversity of Genes Expressed
in High Abundance within Porcine CP
Gene
Abundance
Selected therapeutic
proteins of interest
Transthyretin
23,478
Connective tissue growth factor
20,951
Transforming growth factor 1
9,545
Neuronatin
8,420
Osteoclast stimulating factor
7,242
Tissue factor
6,557
Axotrophin
5,179
Vascular endothelial growth factor
4,260
Neuronal endocrine protein
3,636
Neuronal protein 3
2,781
Pigment epithelium derived factor
1,352
Matrix and adhesion factors
Integrin, 1 binding protein 1
23,753
Laminin receptor 1
15,791
Matrix metalloproteinase 9
9,399
ICAM-1
8,039
Metalloproteinase inhibitor 1 (TIMP-1)
7,983
VCAM-1
7,451
Type III collagen
4,709
Integrin, 5
2,776
Integrin, 4
2,430
Fibronectin
1,737
Integrin,
v
1,847
Cytoskeletal components
-actin
19,715
Vimentin
17,416
Tubulin, 2
15,099
Tubulin, 1
14,403
Villin 2
11,168
Dynein
10,093
Actinin, 1
8,919
In vivo
, CP is implicated in the modulation of neurite outgrowth in the developing
cerebellum
[18]
. Using co-cultures of explanted cerebellum and fourth-ventricle CP
from fetal and infant rats, CP was shown to secrete a soluble neurite-growth factor
