Circadian Organization of the Immune Response: Rat Adjuvant Arthritis as a Model - New Insights to Neuroimmune Biology - page 119

Table 6.1 Summary of Changes in Circadian Rhythms of Submaxillary Lymph
Node Immune Responses during the Preclinical (3rd day) and Acute (18th day)
Phases of Freund's Adjuvant Arthritis in Rats

24-Hour Rhythms Amplitude Acrophase Mean

Preclinical Phase
Cell proliferation a Increased Unchanged Increased

Mitotic response to
Con A

Decreased Unchanged Unchanged

Mitotic response to LPS Unchanged Changed Unchanged

NK cells Absence of rhythm Absence of rhythm Unchanged

B cells Increased Unchanged Increased

T cells Unchanged Unchanged Unchanged

B-T cells Induction of rhythm Induction of rhythm Increased

CD4 cells Induction of rhythm Induction of rhythm Unchanged

CD8 cells Suppression of rhythm Suppression of rhythm Unchanged

CD4-CD8 cells Induction of rhythm Induction of rhythm Unchanged

Noradrenergic activity b Increased Unchanged Increased

Cholinergic activity c Increased Unchanged Increased

Acute Phase
Cell proliferation a Increased Unchanged Increased

Mitotic response to
Con A

Unchanged Unchanged Unchanged

Mitotic response to LPS Unchanged Unchanged Unchanged

B cells Unchanged Unchanged Unchanged

T cells Unchanged Unchanged Unchanged

CD4 cells Unchanged Unchanged Unchanged

CD8 cells Unchanged Unchanged Unchanged

Noradrenergic activity b

Increased Unchanged Increased

Cholinergic activity c

Increased Unchanged Increased

5-HT Absence of rhythm Absence of rhythm Unchanged

Inhibitory amino acids d

Unchanged Unchanged Unchanged

Excitatory amino acids e

Unchanged Unchanged Unchanged

a Estimated from ornithine decarboxylase activity changes.
b Estimated from tyrosine hydroxylase activity and neuronal NE uptake.
c Estimated from 3 H-acetylcholine synthesis and neuronal choline uptake.
d Aspartate, glutamate.
e GABA, taurine.