Biomedical Engineering Reference
In-Depth Information
10
Regulating the Master
B:
From Natural Strategies
to Rationally Designed
Superdrugs
Regulator NF-
κ
Sebo Withoff, Vinay Tergaonkar,
and
Inder M. Verma
CONTENTS
10.1
10.2
Nature's Way of Inhibiting NF-
B.............................................................. 196
10.2.1 Endogenous Inhibition of NF-
κ
B Signaling ................................... 197
10.2.2 Viral and Bacterial Strategies to Inhibit or Prevent NF-
κ
B
Signaling........................................................................................... 199
κ
10.3
Synthetic and Natural Compounds Inhibiting NF-
B ................................ 201
10.3.5 Antioxidants as NF-
κ
B Inhibitors ................................................... 205
10.3.6 Potential Risks of Using NF-
κ
κ
B Inhibitors..................................... 206
10.4
Indirect and Alternative Strategies to Inhibit NF-
B.................................. 206
κ
10.5
B Inhibition in the Postgenomic Era ............................. 208
Tailor-Made NF-
κ
10.1
INTRODUCTION
Transcription factors are often the final arbiters of growth, differentiation, and
development in response to intrinsic or extrinsic signals. Additionally, they
195
