Biomedical Engineering Reference
In-Depth Information
7
NF-
κ
B in the Adaptive
Immune System:
Lymphocyte Survival
and Function
Matthew S. Hayden and Sankar Ghosh
CONTENTS
7.1
7.2
NF-
κ
B in Primary Lymphoid Organs.............................................. 132
7.2.2
NF-
κ
B in Secondary Lymphoid Organs.......................................... 134
7.3
NF-
κ
B and Lymphopoiesis .......................................................................... 137
7.3.1
NF-
B in Early T and B Cell Development ................................... 139
7.3.1.1
κ
NF-
κ
B in Preantigen Receptor Signaling ........................ 139
7.3.1.2
Positive and Negative Selection of Thymocytes.............. 140
7.3.1.3
Negative Selection of B Cells .......................................... 141
7.3.2
NF-
κ
B in Late Stages of Lymphocyte Development...................... 142
7.4
B Cell and T Cell Receptor Signaling to NF-
κ
B............................ 143
7.5
B in Lymphocyte Responses ............................................................... 146
NF-
κ
7.1
INTRODUCTION
The innate immune response is, in many cases, sufficient for the prevention of
microbial invasion and dissemination. For some pathogens, however, innate
responses alone are inadequate for clearance and instead play the crucial role of
alerting the adaptive immune system to the threat of a microbial pathogen. In
Chapter
6
, we discussed aspects of NF-
B function that shape the innate immune response
and how these lead to the initiation of the adaptive response. In this chapter we will
focus on the biological role of NF-
κ
κ
B family members in the adaptive immune
131
