Biomedical Engineering Reference
In-Depth Information
which are often misconstrued as passive barriers, rely on NF-
B in their responses
to physiological and nonphysiological stress. Likewise, the development and periph-
eral homeostasis of leukocytes is critically linked to NF-
κ
κ
B as a regulator of apop-
tosis. Research has tended to focus on NF-
B signaling in the effector functions of
these hematopoietic components of the immune system and its role has thus been
well established in innate responses to all classes of pathogen. In addition, there is
now increasing evidence to support a broader model in which NF-
κ
B also supports
the resolution of inflammatory responses and, in situations that require it, initiation
and coordination of the adaptive immune response.
κ
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