Agriculture Reference
In-Depth Information
:RI+$%
C
$%$
3<5
2+
&2 +
2
39
AC
2+
&2 +
2
40
AC
Fig. 1.12 The space around C-4′ of ABA in the PYR1-ABA-HAB1 crystal structure (PDB:
3QN1) and the C-4′ modified ABA analogues
1.2.3 For Inhibition of CYP707A Enzymes
ABA 8′-hydroxylases, which are CYP707A enzymes, are not inhibited by R -ABA
(Kushiro et al. 2004 ). This strict stereoselective recognition is in marked contrast
to the loose recognition requirements of PYL proteins. Ueno et al. ( 2007 ) revealed
that the C-1 carboxy and C-4′ carbonyl groups play a significant role in stere-
oselective binding. Based on the hypothesis that ABA is anchored via these two
polar groups on the helix I residues in the substrate-binding pocket of CYP707A,
 
Search WWH ::




Custom Search