Agriculture Reference
In-Depth Information
:RI+$%
C
$%$
3<5
2+
&2
+
2
39
AC
2+
&2
+
2
40
AC
Fig. 1.12
The space around C-4′ of ABA in the PYR1-ABA-HAB1 crystal structure (PDB:
3QN1) and the C-4′ modified ABA analogues
1.2.3 For Inhibition of CYP707A Enzymes
ABA 8′-hydroxylases, which are CYP707A enzymes, are not inhibited by
R
-ABA
(Kushiro et al.
2004
). This strict stereoselective recognition is in marked contrast
to the loose recognition requirements of PYL proteins. Ueno et al. (
2007
) revealed
that the C-1 carboxy and C-4′ carbonyl groups play a significant role in stere-
oselective binding. Based on the hypothesis that ABA is anchored via these two
polar groups on the helix I residues in the substrate-binding pocket of CYP707A,
Search WWH ::
Custom Search