Ribonoscopy and Personalized Medicine - Molecular Theory of the Living Cell - page 592

Transcriptomics

Personalized
Medicine

Genomics Proteomics

=

ic -Disspatonics Metabolomics

Fig. 18.3 A network representation of personalized medicine consisting of five nodes and their
inter-relations suggested by the molecular theory of the living cell developed in this topic. The
node labeled ic-dissipatonics is unique because it is the node closest to cell functions, in fact, so
close as to make it indistinguishable from cell functions (see Node E in Fig. 14.7 )

where d 0 is the death rate without any therapy. In other words, diseased cells treated
with drugs will have higher P(D) values than diseased cells without drug treatment
and hence will have lower death rate. It should be pointed out that D in Eq. 18.4 is
synonymous with Node E in Fig. 14.7 . Furthermore, replacing P(D) with P nat (i) in
Eq. 18.1 leads to the Zeldovich-Shakhnovich model of evolution, Eq. 14.32 .P nat (i) is
the probability of the native conformation of the protein that serves as the weakest
link under the i th environmental condition (Sect. 14.7 ) . It is quite surprising and
unexpected to find that the basic mathematical equation developed to account for
biological evolution from the molecular perspective, namely, the Zeldovich-
Shakhnovich model, Eq. 14.32 , can be applied to describe the effect of drug therapy
on the death rate of human patients.