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Fig. 12.21 The genotypic similarity vs. phenotypic distance plots (GSvPD) of the RNA pairs
belonging to different metabolic groups in the budding yeast were divided into the energy-poor
early phase ( blue ) and the energy-rich late phases ( red ). The energy-poor phase obtains during
the first 120 min after switching glucose to galactose when the energy source glucose is absent and
the energy-rich phase obtains between 360 and 850 min when galactose is metabolized to provide
energy. The slopes decrease as the budding yeast cells undergo the cell-state transitions from the
energy-poor early phase to the energy-rich late phase, except for the heme biosynthesis and oxphos
pathways where the slopes either increase or unchanged within experimental error
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