Molecular Mechanisms: From Enzymes to Evolution - Molecular Theory of the Living Cell - page 200

Table 7.1 The thermodynamic and kinetic requirements of ligand-protein interactions. ¼

the Gibbs free energy change accompanying the transformation of the system under consideration
from the initial to the final state, that is,

D G

D G ¼ G final -G initial ;L* ¼ the ligand in the transition-

G { is always positive but G i { can be negative (see i state conformation; D D ¼ 1), zero (see i ¼ 2),

or positive (see i 3). Types I, II and III bindings can be alternatively referred to as the exergonic

(or downhill), equilibrium, and endergonic (uphill) bindings, respectively
Binding

¼

L + P $ [L* P*] $ L'P' D G

Type I D G 1 < 0

DG ‡ 1

D G 1

Type II D G 2 ¼ 0

G ‡ 2

D

Type III D G 3 > 0

ΔG ‡ 3