Conclusions - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 402

Chapter 14
Conclusions

Terrence P. Tougas , Svetlana A. Lyapustina, and Jolyon P. Mitchell

Abstract The concluding chapter to the topic comprises a brief summing up of the
overall content of the previous chapters, followed by a list of learning points to help
clarify the most important aspects of good cascade impactor practice, AIM and
EDA, both for the novice and for the reader with experience who is looking for
“nuggets” of knowledge about these topics.

14.1 Summing Up

This topic is a compilation of current knowledge concerning the use of the CI as the
principal aerodynamic particle sizing technique for those wishing to characterize
the in vitro performance of OIPs. It has been structured to provide initially an out-
line of the cascade impaction method, leading to the formalized development of a
series of interconnected methods for preparation and use of these apparatuses that
has been termed “good cascade impactor practice.” Having established this platform
of basic knowledge, the potential for rapid abbreviated impactor measurement
(AIM) and effective data analysis (EDA) concepts has been explored in relation to
OIP quality control. Although these approaches can readily be used together, EDA