Biomedical Engineering Reference
In-Depth Information
100
Biological Replica Cast
USP Inlet
Proposed USP Inlet
MMI Inlet
80
60
40
20
0
1
10
Aerodynamic Particle Diameter,
100
μ
m
Fig. 12.4
Collection effi ciency data for various inlet geometries at
Q
= 30 L/min; the biological
replica cast refers to the 3 M inlet, and the MMI inlet is the induction port designed for Marple-
Miller impactors. The proposed USP inlet was a new design of induction port that was not adopted
(From
[
14
]
—used with permission).
(
a
) CFC-albuterol. (
b
) CFC-cromoglycate
a
b
100
100
Model
Clinical
Model
Clinical
80
80
60
60
40
40
20
20
0
0
Exhaled
Upper Airway
Lungs
Exhaled
Upper Airway
Lungs
Fig. 12.5
Relative aerosol deposition patterns for the 3M physical model and from clinical HRT
deposition studies (
From
[
14
]
—used with permission
)
deposition further into the airways that are probably impractical in an AIM-based
apparatus. Importantly, Velasquez and Gabrio were able to obtain good agreement
in terms of mass of API deposited in the interior of their biological replica cast as a
function of the mass deposited in these upper airways, the distal airways, and
exhaled mass, with regional deposition data from gamma scintigraphic studies with
adults. In both instances, they used radiolabeled aerosols from CFC-salbutamol
(Fig.
12.5a
) and CFC-cromoglycate (Fig.
12.5b
) MDI-delivered products, repre-
senting aerosols containing lower and higher mass percentages of coarse particu-
late, respectively.
Search WWH ::
Custom Search