Validating AIM-Based Instrumentation and Associated Measurement Techniques - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 318

Fig. 10.41 FPM <5.0μm for DPI product 1 determined by various FSI configurations in comparison
with NGI-measured APSD from measurements of Pantelides et al . (error bars represent ±1 SD for
three replicates) ( From [ 42 ]— used with permission )
Fig. 10.42 Configuration of FSI for follow-on study by Pantelides et al. matching internal volume
more closely to that for the NGI ( From [ 45 ]— courtesy of D. Russell-Graham )
The resulting pressure drop-elapsed time profiles for the same DPI product 1 as was
evaluated in the previous study are illustrated in Fig. 10.43 .
As expected from a comparison of internal dead volumes, the pressure drop-time
profile for the volume-enhanced FSI was much closer to that for the NGI. This
closer match of dead space resulted in a closer agreement in fine particle mass/actua-
tion between the two systems. Figure 10.44 illustrates the near-to-linear correlation
between fine particle mass and air acceleration rate for the FSI, volume-enhanced