Validating AIM-Based Instrumentation and Associated Measurement Techniques - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 285

Fig. 10.5 Effect of number of actuations of Flovent-110 ® on C-FSA-measured data when used
with surfactant-coated collection plates ( From [ 19 ]— used with permission )
Fig. 10.6 Use of liquid ethanol-sensitive paper to diagnose presence of liquid droplets within the
upper stages of the C-FSA. ( a ) Traces confirming liquid ethanol presence with incoming aerosol
to C-FSA from sampling 10-actuations of Qvar™-80, using liquid ethanol-sensitive filter paper
located on collection plate below stage. ( b ) Traces confirming liquid ethanol presence with incom-
ing aerosol to C-FSA from sampling 10-actuations of Qvar™-80, using liquid ethanol-sensitive
filter paper located on collection plate below stage 1 ( From [ 20 ]— used with permission )
The introduction of additional dead space in the T-FSA, compared with the
C-FSA, was found to improve agreement with the ACI in terms of fine particle
mass, a result attributed to the provision of more similar conditions for ethanol
evaporation within the former configuration (Fig. 10.7 ). Overall, the difference
between the data using the slightly modified C-FSA and T-FSA was so small that