Biomedical Engineering Reference
In-Depth Information
Chapter 10
Validating AIM-Based Instrumentation
and Associated Measurement Techniques
Mark Copley, Jolyon P. Mitchell, MÃ¥rten Svensson, J. David Christopher,
Jorge Quiroz, Geoffrey Daniels, Melanie Hamilton,
and Dave Russell-Graham
Abstract The validation of the wide variety of equipment capable of making
abbreviated impactor measurements is a key component providing proof that the
AIM concept works in practice. This chapter provides a comprehensive collection
of validation experiments that have been provided by a variety of different laborato-
ries, mainly through the support of the Cascade Impactor sub-team of the European
Pharmaceutical Aerosol Group (EPAG), who held a Workshop on the topic in
December 2010. These studies have involved the whole range of OIP formats,
thereby increasing confidence in the wide applicability of the approach. A series of
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