Verification of the EDA Concept Through an Assessment of Theoretical Failure Modes, Failure Mode Analysis, and Case Studies with Real Data - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 272

Fig. 9.24 Intentional design change to OIP aerosol assessed by EDA

Individual Profiles Mean Profiles

25 25

20 20

15 15

10 10

5 5

0 0

0.1 1.0 10.0 100.0 0.1 1.0 10.0 100.0

Aerodynamic diameter ( m m)

Fig. 9.25 Multistage CI-measured APSD profi les for product C; the blue lines represent the origi-
nal design, and the red lines were obtained from the modifi ed design to the OIP