Biomedical Engineering Reference
In-Depth Information
Table 1.3
“Road map” for EDA-related metrics
Measurement scenario
Metric
Primary purpose
Determination method
Fractionation by
Full-resolution
Impaction
and
Measurement by
Assay of each
Individual
Deposition sites
API mass deposited on an individual
CI stage (
M
i
)
Product characteriza-
tion in vitro
comparison
Direct quantifi cation after recovery and API assay
Area under the curve (
AUC
) of the
mass- weighted APSD
Integration of continuous form of mass-weighted
APSD as function of aerodynamic diameter
Mass median aerodynamic diameter
(
MMAD
)
Statistical, graphical
,
or mathematical
estimation of
the central tendency of the mass-weighted APSD as the
size that corresponds to the 50th mass percentile
Total (emitted) mass from the OIP
(
TM
)
Product characteriza-
tion Product
acceptance
in vitro comparison
Mathematical
: direct sum of API mass recovered from
both sizing and non-sizing components of CI system
Units
API mass
deposited
Grouped stages
Product
acceptance
Mathematical
: direct sum of API mass recovered from
selected collections of adjacent stages and external
components of CI system
Fractionation by
Full-resolution or abbreviated
impaction
and
Measurement by
Assay of each
Individual
Deposition sites
Large particle mass (
LPM
)
Product acceptance
Mathematical
: direct sum of API mass recovered from
stages with
d
50
sizes larger than boundary diameter
Small particle mass (
SPM
)
Mathematical
: direct sum of API mass recovered from
stages with
d
50
sizes smaller than boundary diameter
Impactor-sized mass (ISM)
[ISM = LPM + SPM]
Mathematical
: direct sum of API mass recovered from
stages with
d
50
sizes both larger and smaller than
boundary diameter
Ratio: LPM/SPM
Mathematical
: ratio of direct sum of API mass
recovered from stages with
d
50
sizes larger than
boundary diameter to mass recovered from stages with
d
50
sizes smaller than boundary diameter
Units
API mass
deposited
(continued)
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