Introduction - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 9

Ratio of LPM to
SPM

Mathematical : ratio of direct sum of API mass measurements for deposition sites with d 50 values larger to direct sum of API mass
measurements for deposition sites smaller than boundary diameter

AUC Integration of continuous form of the

distribution of API mass as function of
aerodynamic diameter derived from CI
calibration

N/A N/A

MMAD Mathematical : estimation of aerodynamic

diameter for 50th percentile of cumulative
APSD of API mass deposited in the CI

N/A N/A

Total emitted
mass ( TM ) ex
OIP

Mathematical : direct sum of API mass associated with non-sizing and sizing components of the CI system