Introduction - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 7

Fig. 1.4 Application of EDA to measurements made by a hypothetical full-resolution CI com-
pared with a single-stage AIM-based system as required for the use of EDA-based metrics; the
symbols “F” and “A” on the stages identify full-resolution and abbreviated CI confi gurations,
respectively

The relationships between all the metrics associated with EDA of an OIP-emitted
aerosol and their linkage with the various determination methods available either by
full-resolution or abbreviated CI apparatuses are summarized in Table 1.2 , and a
summary as to their derivation is given in Fig. 1.5 . Note that EDA can be applied
either to full-resolution CI data or to measurements made by an abbreviated system
(Fig. 1.4 ). It can therefore be linked with the AIM concept, but it is not exclusively
restricted to abbreviated CIs.
Table 1.3 provides a “road map” for readers to familiarize themselves with the
primary purposes for the acquisition of each of the metrics associated with the CI
method, as well as the nature of the metric itself (i.e., whether the outcome from a
direct measurement or by calculation based on other direct measurements).

1.2 Scope

This topic begins with a review of all aspects of the pharmacopeial methods (US
and European) for APSD assessment of OIPs (in Chap. 2 ) . The following chapter
describes the physical processes that underlie aerosol formation from OIPs and the