Performance Characterization of EDA and Its Potential to Improve Decision Making in Product Batch Release - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 184

Fig. 8.9 Ratio metric LPM / SPM versus MMAD from individual CI APSD determinations for a
CFC-formulated MDI
Fig. 8.10 CI stage group 2 versus MMAD from individual CI APSD determinations for a CFC-
formulated MDI
Further, the data for all OIPs exhibited consistent monotonic trends between the ratio
metric, LPM / SPM , and MMAD . Based on a general lack of correlation, neither group
1 (unsized particles) nor group 3 appears to contain any significant information
concerning the mean of the APSD (taken as the MMAD ). With one exception (product