The AIM and EDA Concepts: Why They Are Needed and How They Fit Together - Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products - page 121

a

b

Cumulative Mass-Weighted APSD

99
98

SPM LPM

95
90

full resolution data

80
70

50

30
20

10

5

2 3 4 5 6 7 8 9 10

Aerodynamic Diameter ( µ m)

Fig. 5.5 Nomenclature for a hypothetical abbreviated impactor based on the Andersen nonviable
CI operated at 28.3 L/min for potential OIP QC application (AIM-QC system). ( a ) Mass of API
by component. ( b ) Cumulative API mass-weighted APSD