Biology Reference
In-Depth Information
a
b
c
d
Fig. 2 Bar graphs of the substitution scores for amino acid “L” and “M” as taken from the GONNET250 and
BLOSUM62 substitution matrices. The scores are shown based on an alphabetical ordering of amino acid
letters from the leftmost “A” to rightmost “Z.” (a) GONNET250 row “L;” (b) GONNET250 row “M;”
(c) BLOSUM62 row “L;” (d) BLOSUM62 row “M”
alignments between two sequences. This work uses a version of the
Needleman-Wunsch dynamic programming algorithm with affine
gap scores as discussed in [
2
] to generate each pairwise alignment,
the result of which is merged back into the ensemble alignment of
all previously aligned sequences.
