Chemistry Reference
In-Depth Information
3 Recent Synthesis of Carboranyl-Containing
Porphyrin Derivatives
3.1 Symmetric Carboranyl-Porphyrins and Chlorins
Symmetric carboranylporphyrin derivatives have been prepared either by total
synthesis from boronated monomeric precursors, or from functionalization of a
pre-formed symmetric porphyrin. Both metal-free and metallated derivatives, usu-
ally containing Zn(II), Cu(II), or Ni(II) ions, have been reported. Zn(II)-porphyrins
often show enhanced photosensitizing properties, whereas Cu(II)-porphyrins
show reduced photosensitization and allow tumor detection using PET (
64
Cu) or
SPECT (
67
Cu).
