Chemistry Reference
In-Depth Information
m-H
2
TCP
4
5,10,15,20-Tetrakis[3-(nido-carboranyl)phenyl]porphyrin
MnDMPyFPC
5,15-(4-
N
-methylpyridyl)-10-(pentafluorophenyl)Mn(III)
corrole
MnTDEt
Est
PyP4
5,10,15,20-Tetrakis(4-
N
-diethylesterepyridyl)Mn(III)
porphyrin
MnTMPyC
5,10,15-(4-
N
-methylpyridyl)corroleMn(III)
MPIX
Mesoporphyrin IX
NiTPPS4
5,10,15,20-Tetrakis[4-sulfonatophenyl] Ni(II) porphyrin
N
-methylmesoporphyrin IX
NMM
NMR
Nuclear magnetic resonance
p-H
2
TCP
4
5,10,15,20-Tetrakis[4-(nido-carboranyl)phenyl]porphyrin
PDT
Photodynamic therapy
poly(dA-dT)
Poly(deoxyadenylic-deoxythymidylic)acid
poly(dG-dC)
Poly(deoxyguanylic-deoxycytidylic) acid
RLS
Resonance light scattering
RNA
Ribonucleic acid
T
m
Melting temperature
trans
-H
2
Pagg
5,15-Bis(4-
N
-methylpyridyl)-10,20-diphenyl porphyrin
VCD
Vibrational circular dichroism
Zn(II)TMPyP4
5,10,15,20-Tetrakis(4-
N
-methylpyridyl)Zn(II)porphyrin
ZnPz8+
2,3,7,8,12,13,17,18-Octakis(4-
N
-methylpyridyl)
Cu(II) porphyra zine
ZnTPPS4
5,10,15,20-Tetrakis[4-sulfonatophenyl] Zn(II) porphyrin
1
Introduction
As a result of Watson-Crick hydrogen bonds,
stacking, and electrostatic
repulsion between the negatively charged phosphates, DNA mostly forms double-
helical structure vive. Depending on the sequence and the environment, the duplex
can exist in various conformations, from the most commonly found right-handed B
form to the compact A form and the unusual left-handed Z form (Fig.
1
).
However, DNA does not exist exclusively as duplex but can also form various
secondary structures. Watson-Crick hydrogen bonds form the abovementioned anti-
parallel duplex, but alternative base pairing (Hoogsteen, reverse Hoogsteen, etc.)
allows the formation of triplex and quadruplex structures. These structures might be
responsible for the regulation of some genes [
1
]. RNA can adopt single- and double-
helical structures, as well as several conformations depending on sequences and
biological roles [
2
]. Identification of the different structures and specific sequences
of nucleic acids, by functional probes, might allow to know the mechanism and treat
some diseases.
Interactions of natural products with genetic material (DNA and RNA) have
been at the center of large number of studies for several years. Over regulatory
protein gene expression, as DNA and RNA polymerases or releasing factors that
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