Chemistry Reference
In-Depth Information
3 Multimodality Agents: Advantages of Nanoparticles . ...................................... 18
3.1 Polyacrylamide-Based Nanoparticles .................................................. 21
4 Conclusion and Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26
Abbreviations
AHM
3-(Acryloyloxy)-2-hydroxypropyl methacrylate
APMA
N
-(3-Aminopropyl)methacrylamide
CA
Contrast agent
CE
Contrast enhancement
CLIO
Cross-linked iron oxide
CT
Computed tomography
DOTA
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
DTPA
Diethylene triamine pentaacetic acid
FDA
Food and drug administration
FDG
Fluorodeoxyglucose
FITC
Fluorescein isothiocyanate
FMT
Fluorescence-mediated tomography
FRET
Fluorescence resonance energy transfer
GQL
Good quality of life
3-(1
0
-hexyloxy)ethyl-3-devinyl pyropheophorbide-alpha
HPPH
ICG
Indocyanine green
MB
Methylene blue
MRI
Magnetic resonance imaging
NIR
Near infrared
NP
Nanoparticle
PAA
Polyacrylamide
PDT
Photodynamic therapy
PEG
Polyethylene glycol
PET
Positron emission tomography
PS
Photosensitizer
ROI
Region of interest
SPECT
Single-photon emission computed tomography
US
Ultrasound
1
Introduction
1.1
Importance of Imaging
Heart disease remains the major cause of death among Americans; however, public
awareness coupled with improved diet and medicines has led to a drastic reduction
in annual number of deaths per 100,000 people [
1
]. Unfortunately even with
