Biomedical Engineering Reference
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subjected to LC-MS analyses. Three N-Hcy-Lys-peptides containing
α
-Lys562,
β
-Lys385 are identified in fibrinogen isolated from CBS-deficient
patients [215]. These three in vivo N-homocysteinylation sites are the predominant
sites for fibrinogen N-homocysteinylation in vitro (Fig.
5.3
).
-Lys344, and
γ
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