Chemistry Reference
In-Depth Information
MeO
OMe
1.
HO
Li
OTBDMS
O
NaH, THF, -78˚C, 4h
Br
Br
2
. NaH, CH
3
I, THF, 0˚C-rt, 16 h
3
. TBAF, THF, rt, 12 h
49%
68
63
OH
PhI(OAc)
2
THF-MeCN
H2O
r.t., 2h
71%
MeO
OMe
MeO
OMe
1
. NaH, THF,-78˚C, 2h
2
.
OMe
HO
Br
Br
Li
Br
Br
THF,-78˚C, 4h
3
. NaH, CH
3
I, THF,
0˚C-r.t., overnight
51%
69
OMe
O
70
OMe
MeO
1
. sodium
naphthalenide
THF, -78˚C
Bpin
Bpin
Pd(PPh
3
)
4
, Cs
2
CO
3
MeO
2
. I
2
48%
DMF-Isopropanol
120˚C, 20h
12%
[6]CPP
MeO
71
Fig. 33 The first synthesis of [6]CPP, the smallest to date [
49
]
Fig. 34 Crystal structure of highly-strained 71 (
left
) and [6]CPP (
right
)[
49
]