Secondary and Tertiary Structure Prediction of Proteins: A Bioinformatic Approach - Complex System Modelling and Control Through Intelligent Soft Computations - page 538

Fig. 1 Flowchart for selecting the most accurate algorithm for prediction of the target sequence
against three categories of tertiary structure prediction

the energy landscape. Hence, ab initio algorithm actually searches the entire pos-
sible conformational space of a target sequence, in order to find the native state

among all conformations.
For example, if we consider only three allowed conformations per residue, then a
protein of 200 residues can have 3 200 different conformations (Runthala and
Chowdhury 2013 ). Hence, searching this huge conformational space will be extre-
mely challenging task. This is the most dif

cult category of protein structure pre-

diction among all the three different methods of structure prediction which