MicroRNAs and Robustness in Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic, and Genetic - Systems Biology of Metabolic and Signaling Networks - page 87

Neurons

miRNA 191

Engrailed

GATA-6

MEK

c-MyC

miRNA 302

p53

Caspases
Apoptosis

miRNA 34

Proliferation

Fig. 4.14 Top : Connection between hippocampus neural network and p53 through Engrailed
regulation network, with balance (activations in red , inhibitions in green ) between apoptosis and
proliferation. Bottom : Sequential and parallel attractors of the cell cycle network (E2F box)

We see in Fig. 4.14 that the gene Engrailed is not isolated, but is located at the
intersection of four important networks: the Engrailed control network centered on
MAPK and controlled by miRNA191, the p53 regulation network (Fig. 4.15 ), the