MicroRNAs and Robustness in Biological Regulatory Networks. A Generic Approach with Applications at Different Levels: Physiologic, Metabolic, and Genetic - Systems Biology of Metabolic and Signaling Networks - page 81

Glucose

Pentose phosphate pathway

Glucose
6-phosphate

Fructose
6-phosphate

Fructose
1,6-biphosphate

Phosphoglycer
aldehyde
(PGA)

Phosphoglycer
aldehyde
(PGA)

Pyruvic acid

Pyruvic acid

NADH

NAD +

miR 301

L-lactate

miR 3 4

mitomiR 1974

miR 136

tRNA

mitomiR 1976

mitomiR 1978

mitomiR C 116

mitomir CSB D 353

Fig. 4.13 Top : Connection between the glycolysis pathway of neurons and astrocytes through the
lactate flux, controlled by ANT (green) and F 1 ATPase ( red ) inside the mitochondrial inner
membrane. Middle : Glycolysis coupled to oxidative phosphorylation, with indication of the PFK
kinetics with its effectors (activators and inhibitors). Bottom : indication of the main miRs and