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Fig. 11.7 Mitochondrial Interactosome. (a) Confocal image of a cardiomyocyte labeled with
MitoTracker Red for mitochondria; scale bar 14
m. (b) Scheme depicting the mitochondrial
interactosome, a macromolecular complex formed by the ATP synthasome, in turn constituted by
ATP synthase (subunits in different colors), adenine nucleotide translocase (ANC, orange ),
inorganic phosphate carrier (PIC, yellow ), coupled to the respiratory complexes (I-IV, purple
circles ) in the mitochondrial inner membrane (MIM), octameric mitochondrial CK (MtCK,
backbone structure with dimers in different color) in the intermembrane space (IMS) and the
voltage-dependent anion channel (VDAC, gray-blue ) in the mitochondrial outer membrane
(MOM) interacting with cytoskeletal proteins tubulin ( gray , surface structure representation)
and putative linker protein (LP, purple ). Metabolite fluxes are indicated by arrows in different
colors. For ATP synthase, subunits of the F 1 part ( greek letters ) and F 0 part ( latin letters ) are
indicated, as well as the rotation of the rotor ( yellow arrow ). For the respiratory chain, proton
pumping (H + , yellow arrows ) and some redox centers (FMN, FAD) are indicated, as well as the
two electron carriers coenzyme Q (CoQ/CoQH 2 ) and cytochrome c (cytc). Adapted from
(Timohhina et al. 2009 ) and (Schlattner et al. 2009 ) with permission. Art work of the ATP
synthasome in this figure was reproduced with kind permission from P.L. Pedersen and is the
result of the combined efforts of Drs. Young H. Ko and David J. Blum; MtCK structure and
membrane topology is reproduced from (Schlattner et al. 2006b ) with permission
μ
cells, the heterodimeric tubulin
II and VDAC form a supercomplex with MtCK
and the ATP synthasome—the mitochondrial interactosome (MI) (Fig. 11.7b )
(Timohhina et al. 2009 ). Within this supramolecular structure, ATP and ADP
cycle between ATP synthasome and MtCK maintaining oxidative phosphorylation
effectively coupled to the synthesis of PCr.
αβ
In the MI, MtCK functions
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