Systems Biology Approaches to Cancer Energy Metabolism - Systems Biology of Metabolic and Signaling Networks - page 229

Moreover, integral kinetic modeling of glycolysis, KC, and OxPhos in cancer cells,
using modular approaches for computational modeling (van Gend and Snoep 2008 ;
Cortassa and Aon 2012 ; Mosca et al. 2012 ), is a future task that will most likely help
to identifying suitable targets in the two exclusive energy provider pathways and
that may lead to envision successful multi-target therapeutic strategies (Moreno-
S ´ nchez et al. 2010 ; Mosca et al. 2012 ).

Acknowledgements The present work was partially supported by the following grants from
CONACyT-M ´ xico: Nos. 180322 (AM-H); 107183 (SR-E); 80534 and 123636 (RM-S); and
83084 and 178638 (ES); and from the Instituto de Ciencia y Tecnolog ´ a del Distrito Federal
No. PICS08-5 (RM-S).

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