Systems Biology Approaches to Cancer Energy Metabolism - Systems Biology of Metabolic and Signaling Networks - page 224

Table 9.5 Flux control coefficients obtained with a kinetic model using the complete set of isoforms expressed in HeLa cells

C J
Ei
Normoxia Hypoxia

Model with total
isoform ratios

Model with total
isoform ratios Enzyme Control model Control model

GLUT 0.37 0.42 0.41 0.43

HK 0.09 0.07 0.13 0.13

HPI 0.05 0.03 0.07 0.07

PPP 0.009 0.009 0.006 0.006

Glycogen synthesis 0.1 0.1 0.08 0.07

Glycogen degradation 0.57 0.55 0.41 0.40

PFK-1 0.05 0.04 0.07 0.06

ALDO + TPI + GAPDH + PGK + PGAM + ENO + PYK + LDH 0.006 0.006 0.03 0.03

MPM 0.004 0.004 0.002 0.001

TK 0.014 0.014 0.01 0.01

ATPases 0.05

PPP Pentose phosphate pathway, MPM Mitochondrial pyruvate metabolism. Underlined bold values indicate the main flux-controlling steps under each
particular condition.

0.03 0.02 0.04