Systems Biology Approaches to Cancer Energy Metabolism - Systems Biology of Metabolic and Signaling Networks - page 220

Table 9.2 Flux control coefficients (CJEi) obtained with a kinetic model of glycolysis in HeLa cells

C J
Ei
PFK-L Enzyme Control GLUT3 HKI GLUT3/HKI GLUT3/HKI/PFKL

GLUT 0.37 0.23 0.47 0.35 0.33 0.32

HK 0.09 0.23 0.04 0.1 0.17 0.19

HPI 0.05 0.1 0.02 0.04 0.07 0.06

PPP 0.009 0.005 0.009 0.009 0.004 0.004

Glycogen synthesis 0.1 0.06 0.1 0.1 0.05 0.06

Glycogen degradation 0.57 0.33 0.56 0.58 0.27 0.29

PFK-1 0.05 0.16 0.02 0.07 0.14 0.2

ALDO + TPI + GAPDH + PGK + PGAM + ENO + PYK + LDH 0.006 0.05 0.003 0.006 0.07 0.05

MPM 0.004 0.001 0.004 0.003 0.003 0.0005

TK 0.014 0.009 0.014 0.015 0.007 0.008

ATPases 0.03 0.05 0.013 0.05 0.001 0.07

PPP pentose phosphate pathway, MPM mitochondrial pyruvate metabolism