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Fig. 5.13 Mitochondrial membrane potential oscillations in myocytes of the intact heart. (a, b)
After 2-3 min of normoxic perfusion with Ca
2+
-free Tyrode's buffer, the
m
signal (TMRE
fluorescence) became unstable and spontaneous oscillations were observed. Sustained oscillations
in
ΔΨ
m
were observed for several minutes in the cell indicated by the
yellow dashed line
in panel
a. Both intracellular and intercellular heterogeneity of
ΔΨ
m
is evident in the epicardial optical
sections.
Scale bar
in a equals 20
μ
m. Reproduced from Slodzinski, Aon, O'Rourke (2008) J Mol
Cell Cardiol 45, 650-660
ΔΨ
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